Alveoli

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Alveoli

The alveolar ducts, feed the alveolar sacs where pores connect one alveolus to the adjacent alveolus. 

Some exchange occurs in the respiratory bronchiole. However, the alveoli of the alveolar ducts and sacs are where most gas exchange transpires.  Here the walls of the alveoli, devoid of smooth muscle, are surrounded by a web of elastic fibers. 

Cells

The simple squamous epithelia are called type I pneumocytes or alveolar cells. They facilitate gas exchange between the air of the alveoli and the blood in the capillaries surrounding the alveoli. The respiratory membrane is composed of these type I pneumocytes fused to the endothelial cells of the surrounding blood capillaries. 

Scattered among the type I pneumocytes are the surfactant-making type II pneumocytes also called great alveolar cells. These cells appear as simple cuboidal cells with a dome-shaped apical surface projecting into the lumen of the alveolus. A certain level of alveolar surface tension is needed to help the lungs decrease in volume passively during expiration. However, surfactant is needed to break up that surface tension. By doing this, surfactant makes it easier to inhale with less effort. It increases what is known as compliance. Compliance is the ability to produce pressure changes with very small changes in volume.  

Alveolar macrophages are monocytes that have permanently moved into lung tissue. They roam the lung tissues. They also engulf any foreign material for immune surveillance.

Illustration showing the structure of alveoli, the air sacs in the lungs where gas exchange occurs. Alveoli are depicted as rounded, interconnected sacs branching off a bronchiole-like structure. Capillaries are shown intertwined within the walls of the alveoli.
Figure 1: Alveoli structure. Diagram of air sacs in the lungs with capillaries.
Microscopic view of lung tissue showing round alveoli, the air sacs of the lung, surrounded by capillaries and lined with simple squamous epithelium. An alveolar macrophage, a type of immune cell, is present in the lumen of one alveolus. Capillaries show single file erythrocytes scattered throughout the image.
Figure 2: Lung tissue with alveoli composed of Type I and II pneumocytes. Unattached alveolar macrophages roam free among the cells.
Microscopic image displaying the structure of alveoli in the lung, with various cells labeled. Type I and Type II pneumocytes and alveolar macrophages are identified with green lines pointing to the different cells within an alveolus. Small, dark nuclei are visible within the cells
Figure 3: Labeled alveoli showing Type I & II pneumocytes and alveolar macrophages.

Figures 2 & 3: Lung, H&E, 20X Slide 129
All by University of Michigan Histology, licensed under CC BY-NC-SA 3.0.

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