Mouth to Stomach: Starting the Breakdown

Time To Read

2–3 minutes

Date Last Modified

17

CHART CLUE

From age 19, Stina’s worst days were abdominal: sudden, severe belly pain with fever that sent her to emergency rooms – and once, at 19, cost her a perfectly healthy appendix. The same fever-and-pain attacks returned for a decade, labeled appendicitis, then gastroenteritis, then IBS, then ‘functional’ pain; lately they are joined by quiet malabsorption – loose stools, bloating, and weight loss. Recurrent attacks plus a normal-appendix surgery, repeatedly shrugged off

Digestion begins before the first swallow. In the mouth, teeth shear and grind food into smaller pieces – mechanical digestion – while the salivary glands flood it with saliva, whose enzyme amylase starts breaking down starch and whose mucus binds the result into a slippery bolus. The tongue pushes that bolus to the pharynx, and swallowing becomes briefly involuntary: the epiglottis folds down over the larynx so food takes the correct fork into the esophagus rather than the airway. The esophagus then delivers it to the stomach not by gravity but by peristalsis – which is why a person lying flat, or an astronaut, still swallows successfully.

The stomach is a muscular bag that mixes and marinates. Gastric pits in its lining release hydrochloric acid, bringing the contents to a pH near 2, and the enzyme pepsin, which begins dismantling proteins; the churning produces a soupy mixture called chyme. A thick layer of mucus and bicarbonate normally shields the stomach’s own wall from this acid. When that defense is overwhelmed – by reflux of acid up into the esophagus, or by the bacterium Helicobacter pylori or NSAIDs eroding the lining – the result is heartburn or a peptic ulcer. Stina’s chronic heartburn belongs to this everyday category of upper-GI trouble; importantly, it is not the source of her attacks, and learning to separate the two is part of reading her chart correctly.

Chyme leaves the stomach in squirts – and enters the organ where almost all real absorption happens, and where the gut keeps a standing army. Next: the intestines.

PREVIOUS

One Long Tube, Four Layers

NEXT

The Intestines: Absorption and the Gut’s Immune Watch

List of terms