Dorsal Root Ganglia

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Histological slide of a dorsal root ganglion stained purple, showing clusters of large, round neuronal cell bodies with centrally or eccentrically located nuclei. The surrounding myelin sheaths appear white, encasing nerve fibers extending from the ganglion
Figure 1: Histological slide of a dorsal root ganglion stained purple, showing clusters of large, round neuronal cell bodies

The axons and cell bodies of a dorsal root ganglion can be seen here in cross section.

Each spinal nerve has two dorsal root ganglia – one on the left and one on the right.  The dorsal (or posterior) root branches off of the spinal nerve as you travel medially into the spinal cord.  Just before the dorsal root enters the spinal cord is a bulbous dorsal root ganglion.  Conversely, there is no ventral root ganglion. This absence allows you to easily tell which is the dorsal direction. You can also identify which is the ventral direction on a transverse cut of the spinal cord. 

The dorsal root carries axons of sensory neurons only.  These neurons are unipolar. Their cell body is located off of the axon. It is not at the same location as the dendrites.  The axon of the unipolar neuron enters the spinal cord. It synapses with other neurons in the gray matter. The unipolar cell bodies are aggregated together in the dorsal root ganglion.  The cell bodies are not myelinated. Therefore, dorsal root ganglia can be better visualized by a silver stain, as is with most nervous tissue.

Low-power magnification histological slide of a pink-stained dorsal root ganglion (DRG) adjacent to the spinal cord. The DRG contains large, round neuronal cell bodies surrounded by satellite cells, while the spinal cord shows a butterfly-shaped gray matter region in the center, surrounded by white matter
Figure 2: Low-power magnification histological slide of a pink-stained dorsal root ganglion (DRG) adjacent to the spinal cord
Low-power magnification histological slide of a pink-stained dorsal root ganglion (DRG) adjacent to the spinal cord. The DRG contains large, round neuronal cell bodies surrounded by satellite cells, while the spinal cord shows a butterfly-shaped gray matter region in the center, surrounded by white matter
Figure 3: Low-power magnification histological slide of a pink-stained dorsal root ganglion (DRG) adjacent to the spinal cord
High-power magnification histological slide of a transversely cut nerve, stained pink. Numerous circular nerve fibers are visible, each surrounded by a thin endoneurium layer. The myelin sheaths appear as clear rings around the axons, with perineurium outlining nerve fascicles
Figure 4: High-power magnification histological slide of a transversely cut nerve, stained pink

All Figures Spinal cord and dorsal root ganglion, H&E, Slide 065-2
All by University of Michigan Histology, licensed under CC BY-NC-SA 3.0.

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