Urethra

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Epithelial Cells

Urethras can vary in length depending on the placement of the bladder and other pelvic organs. Toward the trigone of the bladder, the urethra is made of transitional epithelial tissue. This tissue has characteristic cuboidal cells with a dome shape on the apical surface. As the urethra approaches the external urethral orifice, it transitions into stratified squamous tissue. This then seamlessly turns into the cutaneous membrane. As with many orifices, the stratified squamous cells allow some to be lost as urine exits with no consequences.

Longer Lengths

Short urethras are pretty straighforward in their transition from bladder connection to external urethral orifice. Urethras that involve a penis have more sections to them, usually named for the surrounding tissue. For example, the prostatic urethra runs through the prostate gland, located around the trigone of the bladder. The prostatic urethra collects output from the ureter and the ejaculatory duct (an extension of the vas deferns). When it exits the prostate, it becomes the membranous urethra for a very short segment. Then it dips into the erectile tissue of the penis. There, it becomes the spongy urethra and is surrounded by the corpus spongiosum, one of three erectile bodies.

Urethra lined with epithelial tissue stained in purple.  Surrounding smooth muscle is pink stained.  Human urethra
Figure 1: Prostatic urethra lined with epithelial tissue stained in purple. Surrounding pink-stained tissue is prostate gland and smooth muscle.
Transitional epithelial tissue lining the lumen of the prostatic urethra.
Figure 2:Transitional epithelial tissue lining the lumen of the prostatic urethra.
Spongy urethra lined with something that looks like a stratified tissue with a cell shape somewhere between cuboidal and columnar.
Figure 3: Spongy urethra lined with something that looks like a stratified tissue with a cell shape somewhere between cuboidal and columnar.

Figures 1 and 2: Prostate human Slide 281
Figure 3: Penis cross-section human Slide 286
All by University of Michigan Histology, licensed under CC BY-NC-SA 3.0.

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