Neutrophils

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Light microscopy image of stained human blood. Many anucleate, biconcave, pink erythrocytes are dispersed across a light background. Two larger, speckled neutrophils with multi-lobed, dark purple nuclei are visible. The neutrophils appear round with a slightly textured and gray-violet cytoplasm. Illumination appears even.
Figure 1: Blood smear with red blood cells and two neutrophils; the immune system cells have multi-lobed, dark purple nuclei.

Neutrophils are a type of white blood cell (leukocyte). They resemble an EMT or a paramedic. These cells go where the patient is. They are capable of administering a variety of treatments.

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Neutrophils are granulocytes, along with basophils and eosinophils.  They can be easily differentiated from the other two granulocytes by their characteristic multilobed nucleus.

Nucleus

Neutrophils have a distinct feature. They are differentiated from the other granulocytes by a multilobed nucleus with at least 2 lobes. Sometimes, they can have as many as 5 lobes connected by thin strands.  Because of these nuclei, neutrophils are sometimes called “polymorphonuclear leukocytes” or “polys.”

High-magnification micrograph of a blood smear. The field is filled with biconcave, pink-stained erythrocytes (red blood cells) and two purple neutrophils with multi-lobed nuclei; these leukocytes are the focus of the image. The background is a clear matrix of plasma. The image shows diagnostic hematology and cellular components within an biological fluid.
Figure 2: Microscopic view of blood cells, with neutrophils visible among the red blood cells.

Cytoplasm

As a granulocyte, neutrophils have granules in their cytoplasm.  These granules are usually smaller than those found in eosinophils and basophils.  Unlike the other granulocytes, the granules are not as densely packed. Sometimes, the space between them appears pink. This is due to the staining properties of proteins in the cytoplasm.

Function

Neutrophils are one of the two leukocytes that are microphages (the other being eosinophils)  These microphages circulate in blood.  When tissues are injured, various chemicals are released to attract leukocytes to the area.  Neutrophils are able to recognize these substances. They exit blood circulation and enter tissues. There, they begin triage with the variety of substances in the cytoplasm.

Confused With

Neutrophils can be easily confused with basophils.  The granules of basophils are larger and the nucleus of a basophil can barely be seen.  They can also be confused with eosinophils, but the characteristic red color of the eosinophil granules tells them apart. 

All Figures: Slide 86X Human blood smear, Giemsa stain, 86X scan from hematopathology normals collection
All by University of Michigan Histology, licensed under CC BY-NC-SA 3.0.

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