Smooth Muscle

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Smooth muscle is one of the two muscles over which you have no control.  Smooth muscle forms sheets of spindle-shaped cells. These cells are aligned in the same direction. They contract in a coordinated fashion.  Your tube-like, hollow organs of the gastrointestinal (GI) tract have two sheets of smooth muscle around them. This includes the esophagus and the small intestine. This arrangement creates a coordinated contraction called peristalsis.

Interface of longitudinally and transversely sections smooth muscle fibers
Figure 1: Interface of longitudinally and transversely sections smooth muscle fibers

Much like the cylinder shaped cells of skeletal muscle, the spindle-shape of smooth muscle can be hard to see. This is especially true in a 2D impression.  Most pictures of smooth muscle will be cut as in a cross section of the spindle shaped cells. This reveals a circular 2D impression. 

The darkly-stained nuclei of smooth muscle fibers are almost dead center. This is different from the nuclei that are pushed to the side of skeletal and cardiac muscle fibers.  This resembles squamous epithelial cells. However, there would always be a lumen, which is an open space on a slide showing epithelial tissue.

I have never established the ability to recognize this tissue without difficulty.  When I absolutely can’t tell what a tissue is, I usually default to smooth muscle.  I guess that’s like choosing C for every  multiple choice answer you don’t know.

Histological cross section of smooth muscle
Figure 2: Histological cross section of smooth muscle

Sheets of Smooth Muscle

Smooth muscle is usually found in a sheet, but there are some single unit smooth muscle cells in your body.  Each hair in your skin is attached to a single smooth muscle fiber.  These single units are all controlled together; if one contracts, they all contract. When the muscle fibers contract, your hairs “stand on end.” This is like the reaction your neck hairs would have if you were startled.


Other smooth muscle in your body is found in sheets of the spindle-shaped cells.  These sheets contract in a coordinated fashion via the nervous system.  Smooth muscle doesn’t have neuromuscular junctions like skeletal muscle. It has bundles of nervous tissue called varicosities. These varicosities innervate and control the smooth muscle.


Smooth muscle surrounding hollow organs are usually found in two sheets of alternating orientation of the muscle fibers.  An inner or deep layer of smooth muscle circles the tube-like organ. The orientation is much like wrapping a scarf around your neck.  When these muscle fibers contract, the diameter of the tube-like hollow organ gets smaller.  There is an outer or superficial layer of smooth muscle. The spindle-shaped muscle fibers orient long-wise along the hollow tube-like organ.  When these contract, the tube shortens, much like when you see an inch worm shorten while walking.


When these two sheets of smooth muscle contract in an alternating pattern, they produce a motion called peristalsis.  This coordinated contraction moves the contents of the hollow organ.  This process occurs in your esophagus, small intestine, and large intestine. It moves the contents to the next organ in the sequence.    

Figure 1: Bladder, human, H&E, 40X Slide 212
Figure 2: Esophagus and stomach, H&E, 40X Slide 155
All by University of Michigan Histology, licensed under CC BY-NC-SA 3.0.

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