Why every culture came back negative

Stina spent years being tested for infections she did not have. Each negative result was filed as a failure to find the cause, when it was the cause: inflammation with no pathogen in it is not a missed infection, it is autoinflammation.

The distinction is cellular. An infection is the immune system responding to something foreign. Autoinflammation is the same machinery firing on its own, inside the cell, with nothing outside to blame. Colchicine works because it binds the cytoskeleton A network of protein filaments that provide structure, shape, and movement to cells. that machinery runs on.

Chart Clue #3 — logged

Check everything from Module 3

These activities assess the module as a whole — every part, not just one. Work down from low-stakes self-check to the graded quiz, then consolidate. Each H5P box below is waiting for its shortcode id.

Tier 1 · Self-check — warm up, ungraded

Tier 2 · Graded — the module quiz

Tier 3 · Consolidate — lock in the big ideas

Where this goes next

Module 4 — Making Cells & Proteins. The first clinician who asked about her family instead of her symptomsSubjective experiences reported by the patient (e.g., nausea, fatigue). found the answer in a gene. This module follows the central dogma from DNA to protein, and arrives at the Chart Reveal the whole course has been building toward. Begin Module 4 →