ANATOMY & PHYSIOLOGY I · MODULE 3
Inflammation with no germ in it
A stack of visits ending in the same sentence: no source of infection identified. This module builds the cell and its transport systems, then walks into the one cell where Stina’s disease actually lives.
The findings this module reads together
She always pictured her attacks as something done to her from outside — an infection she kept catching, a bug nobody could name. Every workup came back negative, and every negative felt like a dead end.
The word sterile was on her chart the whole time, and it was the answer, not the absence of one. Inflammation with no pathogen anywhere to find is autoinflammation, coming from inside the cell. To see it you need organellestructures within a cell that perform specialized functions., membranes and transport — and then one look inside a neutrophil.
PATIENT CHART · STINA · CHART CLUE #3
- Repeated — ‘No source of infection identified’
- Cultures — Sterile, every time
- Attacks — Hot swollen joint, self-limited
- Treatment — Colchicine, from the crocus
Seven parts, one chart
Each part opens with a finding from Stina’s chart and asks you to commit to a prediction before any video plays, then alternates short videos with H5P activities. Work them in order.
3.3
Organelles I — Power & Skeleton
Mitochondria, cytoskeleton A network of protein filaments that provide structure, shape, and movement to cells., and where colchicine binds.
ORGANELLES
3.4
Organelles II — The Protein Factory
Where pyrin is built, and why folding matters.
ER & GOLGI
3.6
Crossing the Membrane
Facilitated and active transport, and a drug interaction.
TRANSPORT
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The Evidence Behind the Case
Every step of this module’s reasoning, paired with the peer-reviewed literature behind it.
REFERENCES
What you’ll be able to do
By the end of Module 3 you will be able to:
1
Identify the organelles of a eukaryotic cell and describe their functions.
2
Describe the structure of the plasma membraneThe outer boundary of a cell that controls what enters and exits. and the roles of membrane proteins.
3
Compare diffusion, osmosis, facilitated diffusion, and active transport.
4
Predict cell behavior in hypotonic, isotonicA solution with the same solute concentration as the inside of a cell, maintaining equilibrium., and hypertonicA solution with a higher solute concentration than the inside of a cell, causing water to leave the solutions.
5
Explain the role of the cytoskeleton and how colchicine disrupts it.
6
Distinguish sterile autoinflammation from infection using clinical evidence.
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All pages for Module 3 — The Cell & Its Transport
3.0 Module Overview
3.1 The Cell as the Scene
3.2 Gatekeepers – Membrane Proteins
3.3 Organelles I – Power & Skeleton
3.4 Organelles II – The Protein Factory
3.5 Water on the Move – Tonicity & Diffusion
3.6 Crossing the Membrane – Facilitated & Active Transport
3.7 Inside the Neutrophil + Transport Meets Disease
3.8 Conclusion and Assessment
3.9 The Evidence Behind the Case
All Modules
- Anatomical Language, Membranes & Homeostasis
- Just Enough Chemistry
- The Cell & Its Transport
- Making Cells & Proteins
- The Integumentary System
- The Skeletal System
- The Muscular System
- Nervous Tissue & the Senses
- The Spinal Cord
- The Brain & the Blood–Brain Barrier
- The Autonomic Nervous System
- Special Senses (in developmentThe process of growth and differentiation.)
- The Endocrine System
- Blood
- The Heart
- Blood Vessels
- The Digestive System
- The Respiratory System
- The Urinary System
- Fluids, Electrolytes & Acid–Base Balance
- The Reproductive System
- The Immune System
List of terms
- organelles
- proteins
- cytoskeleton
- diffusion
- plasma membrane
- isotonic
- hypertonic
- development