ANATOMY & PHYSIOLOGY I · MODULE 4
One typo, every cell
The first clinician who asked about her family instead of her symptomsSubjective experiences reported by the patient (e.g., nausea, fatigue). found the answer in a gene. This module follows the central dogma from DNA to protein, and arrives at the Chart Reveal the whole course has been building toward.
The findings this module reads together
The new clinician’s first questions weren’t about the attack at all. They were about her parents, her grandparents, and where her family came from — and they led to a MEFV gene panel.
One substituted amino acidThe building blocks of proteins, consisting of an amino group, carboxyl group, and side chain. in a protein called pyrin, present in every cell since before she was born, copied faithfully at every division. The whole arc of her life turns on that single letter. This module builds the machinery that copies and reads it, so the reveal lands as biology rather than magic.
PATIENT CHART · STINA · CHART CLUE #4
- Family history — The first question anyone asked
- Genetics — MEFV panel ordered
- Result — M694V — pyrin mis-spelled
- Since — Present in every cell, from birth
Seven parts, one chart
Each part opens with a finding from Stina’s chart and asks you to commit to a prediction before any video plays, then alternates short videos with H5P activities. Work them in order.
4.5
It Was in Me Before I Was Born
The cell cycleThe sequence of events in a cell’s life, including growth, DNA replication, and division. and how the typo propagates.
CELL CYCLE
4.7
The Reveal — From MEFV to Diagnosis
The Chart Reveal: a diagnosis, decades late.
CHART CLUE #4
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The Evidence Behind the Case
Every step of this module’s reasoning, paired with the peer-reviewed literature behind it.
REFERENCES
What you’ll be able to do
By the end of Module 4 you will be able to:
1
Describe the structure of DNA and the process of replication.
2
Explain transcription and translationThe process of converting mRNA into a protein. and trace the central dogma end to end.
3
Describe the stages of the cell cycle, mitosis, and meiosis.
4
Explain how a single nucleotideThe basic building block of DNA and RNA, consisting of a sugar, phosphate group, and nitrogenous bas substitution changes a protein.
5
Interpret an autosomal recessive inheritance pattern in a pedigree.
6
Relate the M694V variant in MEFV to the pyrin protein and its function.
Hop to:
← Familial Mediterranean Fever — case home
All pages for Module 4 — Making Cells & Proteins
4.0 Module Overview
4.1 The First Doctor Who Asked
4.2 Copying the Code
4.3 Written in Me the Whole Time
4.4 One Letter — Translation and M694V
4.5 It Was in Me Before I Was Born — The Cell Cycle
4.6 One Typo, Every Cell
4.7 The Reveal – From MEFV to Diagnosis
4.8 Conclusion and Assessment
4.9 Evidence Behind the Case
All Modules
- Anatomical Language, Membranes & Homeostasis
- Just Enough Chemistry
- The Cell & Its Transport
- Making Cells & Proteins
- The Integumentary System
- The Skeletal System
- The Muscular System
- Nervous Tissue & the Senses
- The Spinal Cord
- The Brain & the Blood–Brain Barrier
- The Autonomic Nervous System
- Special Senses (in developmentThe process of growth and differentiation.)
- The Endocrine System
- Blood
- The Heart
- Blood Vessels
- The Digestive System
- The Respiratory System
- The Urinary System
- Fluids, Electrolytes & Acid–Base Balance
- The Reproductive System
- The Immune System
List of terms
- symptoms
- amino acid
- acid
- cell cycle
- translation
- nucleotide
- development