ANATOMY & PHYSIOLOGY II · MODULE 19
Not a trace. An alarm.
A routine urinalysis at forty-seven showed a trace of protein, noted and left for someone to recheck sometime. This module builds the kidney and follows that single line to the most serious complication in the whole case.
The findings this module reads together
Her kidneys look fine from the outside: two well-sized organs, clean architecture, no stones, no obstruction. But the quantified protein climbs over months from a trace into the nephrotic range, and a biopsy finds AA amyloid in the glomeruli.
This is the chapter the whole course has been moving toward. Years of elevated serum amyloid A, produced faithfully by an acute-phase response that never switched off, have been depositing in the filter. Renal AA amyloidosis is the defining, life-threatening complication of untreated FMF — and it announced itself as a line nobody chased.
PATIENT CHART · STINA · CHART CLUE #19
- Age 47 — Trace protein on routine urinalysis
- Months — Protein climbing to nephrotic range
- Imaging — Kidneys structurally normal
- Biopsy — AA amyloid in the glomeruli
Seven parts, one chart
Each part opens with a finding from Stina’s chart and asks you to commit to a prediction before any video plays, then alternates short videos with H5P activities. Work them in order.
19.1
A Little Protein in the Urine
One line on a routine report, and where it leads.
URINALYSIS
19.3
The Nephron and the Filtration Barrier
The three layers protein should never cross.
GLOMERULUS
19.4
Reabsorption, Secretion, and How Urine Is Made
Filtration is blind; the tubule does the sorting.
TUBULAR FUNCTION
19.6
When the Filter Breaks
Renal AA amyloidosis, localized to the glomerular barrier.
AMYLOIDOSIS
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The Evidence Behind the Case
Every step of this module’s reasoning, paired with the peer-reviewed literature behind it.
REFERENCES
What you’ll be able to do
By the end of Module 19 you will be able to:
2
Identify the parts of the nephronThe functional unit of the kidney that filters blood and produces urine. and describe the glomerular filtrationThe process by which fluid moves out of capillaries into surrounding tissues due to hydrostatic pres barrier.
3
Explain glomerular filtration, tubular reabsorptionThe process of fluid moving back into capillaries from surrounding tissues due to colloid osmotic pr, and tubular secretionThe process of moving substances from the blood into the nephron tubule to be excreted in urine..
4
Describe how the kidney regulates blood volume and blood pressure.
5
Explain proteinuria in terms of a failing filtration barrier.
6
Describe AA amyloidosis and its relationship to a sustained acute-phase response.
Hop to:
← Familial Mediterranean Fever — case home
All pages for Module 19 — The Urinary System
19.0 Module Overview
19.1 A Little Protein in the Urine
19.2 The Kidney from the Outside In
19.3 The Nephron and the Glomerular Filtration Barrier
19.4 Reabsorption, Secretion, and How Urine Is Made
19.5 Master Regulator: Blood Volume, Pressure, and the Path of Urine
19.6 When the Filter Breaks
19.7 Not a Trace, an Alarm
19.8 Conclusion and Assessment
19.9 Evidence Behind the Case
All Modules
- Anatomical Language, Membranes & Homeostasis
- Just Enough Chemistry
- The Cell & Its Transport
- Making Cells & Proteins
- The Integumentary System
- The Skeletal System
- The Muscular System
- Nervous Tissue & the Senses
- The Spinal Cord
- The Brain & the Blood–Brain Barrier
- The Autonomic Nervous System
- Special Senses (in developmentThe process of growth and differentiation.)
- The Endocrine System
- Blood
- The Heart
- Blood Vessels
- The Digestive System
- The Respiratory System
- The Urinary System
- Fluids, Electrolytes & Acid–Base Balance
- The Reproductive System
- The Immune System
List of terms
- anatomy
- urine
- pressure
- bladder
- urethra
- nephron
- filtration
- reabsorption
- secretion
- development