ANATOMY & PHYSIOLOGY II · MODULE 22
Twenty clues, one mechanism
Genetic testing returns two pathogenic MEFV variants and the diagnosis is confirmed. This capstone builds the immune system and then uses it to close the case — every clue in Stina’s chart, traced back to a single defect.
The findings this module reads together
Her flares are abrupt, stereotyped, fever-driven and antibody-negative. ANA, rheumatoid factor and anti-dsDNA have been negative every time they were drawn. Cultures are sterile and antibiotics do nothing. Lymphoid tissue is reactive but the spleen works.
That combination is a fingerprint, and it points at the innate arm rather than the adaptive one. FMF is autoinflammatory, not autoimmune. A hair-trigger pyrin inflammasome floods the system with IL-1β; chronically elevated serum amyloid A follows; AA amyloid deposits in gut and kidney. One pathway accounts for all of it.
PATIENT CHART · STINA · CHART CLUE #22
- Genetics — Two pathogenic MEFV variants
- Serology — ANA, RF, anti-dsDNA negative
- Cultures — Sterile; no antibiotic response
- Biopsy — AA amyloid, gut and kidney
Seven parts, one chart
Each part opens with a finding from Stina’s chart and asks you to commit to a prediction before any video plays, then alternates short videos with H5P activities. Work them in order.
22.1
The Lab Result That Names Everything
Two MEFV variants, and a diagnosis at last.
MEFV
Coming soon
22.2
Two Arms of Defense
Innate and adaptive immunity, and which one is misfiring.
INNATE VS ADAPTIVE
Coming soon
22.3
The Cells and the Lymphatic Organs
Immune cellsThe basic structural and functional units of life., lymphoid tissues, and reactive hyperplasia.
LYMPHATIC SYSTEM
Coming soon
22.4
The Inflammatory Response
The cardinal signsObjective clinical findings observable by a provider (e.g., edema, fever)., and what sterile inflammation means.
INFLAMMATION
Coming soon
22.5
Antibodies, Adaptive Immunity and Memory
Why a clean autoantibody panel is the point.
ADAPTIVE IMMUNITY
Coming soon
22.6
From Pyrin to Amyloid
The whole pathway, and the two points where it is starved.
PYRIN TO AMYLOID
Coming soon
22.7
One Connected Story
Twenty clues, one mechanism, one diagnosis.
CHART CLUE #22
Coming soon
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The Evidence Behind the Case
Every step of this module’s reasoning, paired with the peer-reviewed literature behind it.
REFERENCES
What you’ll be able to do
By the end of Module 22 you will be able to:
1
Distinguish innate from adaptive immunity and identify the cells of each.
2
Describe the organs and tissues of the lymphatic system and their immune roles.
3
Explain the cardinal signs of inflammation and the mechanism behind each.
4
Describe antibody structure, classes, and the basis of immunological memoryThe ability to store and recall information..
5
Distinguish autoinflammatory from autoimmune disease using clinical and laboratory evidence.
6
Trace the pyrin-IL-1β-SAA-amyloid pathway and identify where treatment interrupts it.
Hop to:
← Familial Mediterranean Fever — case home
All pages for Module 22 — The Immune System — Capstone
22.0 Module Overview
22.1 — in developmentThe process of growth and differentiation.
22.2 — in development
22.3 — in development
22.4 — in development
22.5 — in development
22.6 — in development
22.7 — in development
22.8 Conclusion and Assessment
22.9 Evidence Behind the Case
All Modules
- Anatomical Language, Membranes & Homeostasis
- Just Enough Chemistry
- The Cell & Its Transport
- Making Cells & Proteins
- The Integumentary System
- The Skeletal System
- The Muscular System
- Nervous Tissue & the Senses
- The Spinal Cord
- The Brain & the Blood–Brain Barrier
- The Autonomic Nervous System
- Special Senses (in development)
- The Endocrine System
- Blood
- The Heart
- Blood Vessels
- The Digestive System
- The Respiratory System
- The Urinary System
- Fluids, Electrolytes & Acid–Base Balance
- The Reproductive System
- The Immune System
List of terms
- cells
- signs
- memory
- development