Time To Read
Date Last Modified
The Skeletal System · Chapter 7 of 7
She never broke a bone — but a fractureBreaks in bones due to stress or injury. is where ossification runs again in an adult, and the packet’s last page is repair: seven fracture types, four steps, cartilageA flexible connective tissue found in joints, the ear, nose, and rib cage. Cartilage can be of three to spongy to compact. Then the chart. May 2026, age 51: a rheumatologist reads the skeletal column end to end — shins at ten, a knee at twelve, piercings at twenty, a scan at thirty-eight, a disc at forty — and names it once. Chart Clue #6.
The question you will answer
Bone repairs a break by rebuilding itself the way it was first built. What are the fracture types, what are the four steps of repair, and why does the sequence matter? Then: what does a bone do when the inflammation that repairs a fracture is switched on with nothing broken — and how do six skeletal labels read as one?
Opener · Six Labels, One Skeleton · about 2 minutes
The opener is the same narrated animation you will watch in Scene 5.
Watch the opener first. It sets the question; the chapter answers it.
1
Read the chart
Patient chart · Stina
1985 → 2026 · the skeletal column, read end to end
1985 · 10
Night shin and foot pain — “growing pains.” Hot, red, sharp-edged shins with a fever after the mile — “out of shape.”
1986–90 · 11–15
Feet, shins and back ache on concrete — “flat feet.” A loaded spineProminent ridge on the posterior scapula dividing it into supraspinous and infraspinous fossae.. Period-day fevers with a swollen knee, then an ankle — “sprain / reactive arthritis.”
1995 · 20
Cartilage piercings that never healed — “bad piercer.”
2013 · 38
DEXA low for age — “perimenopause.” Calcium and vitamin D.
2015 · 40
L4/L5 disc — like Mom. A back that hurts most on fever nights (Module 9).
May 2026 · 51
Read whole: exertional leg pain and erysipelas-like erythemaRedness of the skin due to increased blood flow, often caused by heat, infection, or inflammation. (minor criteria), monoarthritis with fever (the pattern of a major criterion), sterile synovitis, low BMD, a cytokine-driven skeleton — Chart Clue #6. LPIN2 beside MEFV: the bone gene; a question held open.
Chart clues this module: 6 · logged
Before you go on · your prediction
Six skeletal labels across forty years — growing pains, out of shape, flat feet, a sprain, a bad piercer, perimenopause. The best reading is…
Open the one you lean toward. Nothing is recorded and nothing is revealed — you come back to it at the end.
Six ordinary things that happen to many people, each true on its own day
Ask what each label assumed about bone, and which assumption every one of them shared.
A weak skeleton — some inherited fragility nobody named
Ask whether any bone ever broke, and whether “fragile” explains a knee that fills with a fever.
One inflammatory disease signing its name in bone, cartilage and synovium from the age of ten
Ask what IL-1β does to osteoclasts, chondrocytes and the synovial membrane, and which FMF criteria the chart met at ten and twelve.
From Stina’s diary
2
The story
Three short movements: the case, the anatomyThe study of the structure of the human body. and physiologyThe study of how the body functions., then the tie back to Stina. Each links to the scene where you’ll see it move.
I · Broken and mended
Stina never broke a bone, which the 2013 chart counted as ‘nothing serious’. But a fracture is the one place an adult runs ossification again, and the sequence is the packet’s last lesson. The types first: open or closed says whether the skinThe body’s largest organ, providing protection and regulation. broke; comminuted is three or more pieces; compression is crushed, usually a vertebral body; spiral is twisted; epiphyseal runs through a child’s plate; depressed is pushed inward, a skull; greenstick is a child’s incomplete break. Repair in four steps. One: a hematomaA blood clot that forms at the site of a fracture. forms — torn vessels bleed, the clot kills the osteocytes at the edges, and inflammation moves in. Two: a fibrocartilaginous callus — fibroblasts and chondrocytes from the periosteum and endosteumA thin connective tissue lining the marrow cavity. splint the gap with collagenA structural protein in the dermis that provides strength and elasticity. and cartilage. Three: a bony callus — osteoblasts convert the soft callusThe cartilage and fibrous tissue that forms in early fracture healing. to spongy boneA porous bone tissue found inside bones, providing lightweight support., over weeks. Four: remodeling — osteoclasts and osteoblasts turn the bulge into compact boneDense, strong bone tissue forming the outer layer of bones. and a cavity, over months to years. Cartilage model, spongy, compact: endochondral ossificationBone formation replacing a cartilage model, common in long bones, run again. Every step after the first is driven by the inflammation the clot starts — which is the point.
See it move: Scene 1 · Seven Fractures · Scene 2 · Four Steps to Mend
II · A bone that inflames with nothing broken
Switch the same inflammation on with nothing broken and bone does not repair; it resorbs, aches and, in the long run, thins. IL-1β, IL-6 and TNF tell osteoblasts to display RANKL and to stop making OPG; osteoclastBone-resorbing cells that break down bone matrix. precursors from the monocyte line find RANKL and mature; resorption runs ahead of deposit; the periosteum, dense with nerves, reports. In FMF the skeleton is a documented address: arthritis in three patients of four, a single large joint with the fever; exertional leg pain and erysipelas-like erythema as minor criteria, monoarthritis as a major one; lower bone density in cohorts, worse with every year of delay; back pain and sacroiliitis reported in FMF cohorts (how often varies widely), often without the HLA-B27 gene. A second gene on her 2017 panel, re-read in 2026, sits beside the first. LPIN2, when both copies fail, causes Majeed syndrome: sterile multifocal osteomyelitis from infancy, worst in the tibial metaphyses, with anemiaA condition characterized by a deficiency of red blood cells or hemoglobin, leading to reduced oxyge — an IL-1 disease that lands in bone. She carries one copy. Lipin-2 normally holds back the NLRP3 inflammasome; her MEFV variants make pyrin’s inflammasome fire too easily — two brakes on the same IL-1β. Researchers now study single copies of fever genes, and people who carry variants in more than one fever gene, some of whom are sicker than either variant alone would predict. Whether one faulty copy of each adds up in her bones is a question the module asks and does not answer; the only test that would show it — a whole-body MRI for marrow edemaExcess fluid in interstitial spaces. — has not been ordered, and the narrator says so.
See it move: Scene 3 · The Bone That Inflames Instead · Scene 4 · The Criteria She Met at Ten
III · Read whole
In May 2026 a rheumatologist with the page-two gene in front of her read the skeletal column of the chart the way this module has: the night pain and the hot shins at ten, the concrete years, the knee and the ankle at twelve, the piercings at twenty, the scan at thirty-eight, the disc at forty and the back that hurts worst on fever nights. Six labels — growing pains, out of shape, flat feet, a sprain, a bad piercer, perimenopause — each defensible on its own day, each assuming the same thing: that bone and cartilage are inert, and that a child’s complaint about them is a complaint about growthAn increase in size and number of cells., fitness, shoes or luck. Read together, they are one disease that reaches a living, innervated, immune-populated tissue the way it reaches the skin and the peritoneumThe membrane lining the abdominal cavity and organs.: a periosteum that burns under exertion, a synovium that fills with the fever, cartilage that cannot heal what a cytokine keeps re-injuring, and osteoclasts that run hot for decades until a scan calls the result perimenopause. The skeleton was not aging and was never fragile. It was inflaming. Chart Clue #6 — and the calcium it spent is the thread Module 7 picks up in a muscle.
See it move: Scene 5 · Chart Clue #6
3
Watch · explore · think · check
5 scenes. Each one has a short animation or a slide, something to explore, a true/false spot-check of your thinking, and a quick check. Every scene gives you an evidence card for your board.
How to read the scenes
- Animation (dark teal) — a short animated explainer, one idea each
- Slide (dark teal) — a still to study: a micrograph, a diagram or a map
- Explore (purple) — something to push on while you watch
- Game (purple) — a quick challenge
- Think (gold) — reason it out, then spot-check yourself with a few true/false questions; not graded
- Check (gold) — a quick H5P that scores itself
Scene 1 of 5
Seven Fractures
Open or closed, three pieces, crushed, twisted, through the plate, pushed in, bent — Table 6.2 on one slide.
Slide · in production
Types of Fracture
Seven ways a bone fails — and the one she never had, which the chart counted as reassurance.
Prefer the full lecture? Fractures and Healing (original video on the site)
Game
Name the break
Nine films on the lightbox. Name each break and the force behind it before the key, then predict two patients’ films and weigh what “she never broke a bone” is worth.
Text description of this game
An X-ray lightbox: white bone drawn on black film. Step 1: nine films lettered A to I. A, an adult tibia with a break that winds diagonally down and around the shaft; B, three lumbar vertebrae from the side, the middle body squashed into a wedge shorter at the front; C, a child’s forearm with the radius bent into a bow and cracked partway in from the outside of the bend; D, an adult lower leg with the skin outline shown and the end of an angled break poking out through the skin; E, an adult femur with one straight break across the shaft; F, a skull from the side with one segment of the vault pushed inward; G, an adult femur with three loose fragments between the two main ends; H, an adult lower leg with the skin outline unbroken around an angled, slightly shifted break; I, a child’s knee with a break running along the growth plate and up through the bone above it. For each film choose the force (crush, twist, bend or blow) and the name (open, closed, comminuted, compression, spiral, epiphyseal, depressed, greenstick or transverse). After you commit, each film is labeled. Step 2: two patients, each with a dark film that appears when you commit: a child of 9 who fell off a bike onto an outstretched hand, and a woman of 70 who sat down hard on a kitchen chair. For each, choose the likely fracture (greenstick, epiphyseal, compression, comminuted or spiral) and why (young bone bends; resorption thinned it; a twist around the shaft; or high energy shattered it). After you commit, the child’s film shows a bent, cracked radius and the woman’s a wedged vertebra. Step 3: her 2013 chart counted “never fractured” as reassurance; choose what “she never broke a bone” tells you and what it does not.
Think · not graded
A compression fracture of a vertebral body is how osteoporosis usually announces itself; a greenstick fracture only happens in a child; an epiphyseal fracture threatens growth. Explain each from the bone’s structure, and then say why a woman who has never fractured can still have been losing bone for twenty years.
Spot-check your thinking: true or false?
Check · Drag the Words
Match each fracture to its description.
Evidence card 1
Add it to your evidence board
No fracture on her chart — a factA statement based on direct observation that is repeatedly confirmed. that reassured, and told nobody what the osteoclasts had been doing since 1985.
Scene 2 of 5
Four Steps to Mend
Hematoma, soft callus, bony callus, remodeling — ossification run again, driven by inflammation.
Animation · in production · 2 min
Four Steps to Mend
A tibiaShinbone; large, weight-bearing medial bone of the lower leg. snaps. Vessels bleed into a hematoma within hours; osteocytes at the edges die; neutrophils and macrophages arrive. Days: fibroblasts and chondrocytes from the periosteum and endosteum build a fibrocartilaginous callus, an internal and an external splint. Weeks: osteoblasts turn it to spongy bone — the bony callus. Months to years: osteoclasts and osteoblasts remodel the bulge to compact bone and reopen the cavity. The three stills — cartilage, spongy, compact — line up beside Chapter 4’s. Caption: the same sequence, started by a clot. Terms: fracture hematoma, granulation tissue, internal and external callus, closed vs open reduction (the orthopedist).
Prefer the full lecture? Fractures and Healing (original video on the site)
Explore
Mend the bone
A cast room with a timeline on the wall. Put four stages in order, time them and staff them, line them up beside the embryo, then take the inflammation away and watch the callus.
Text description of this explore
A cast room. Step 1: four shuffled tiles to put in order with up and down buttons: a clot fills the gap and the osteocytes at the broken edges die; collagen and cartilage bridge the gap, inside and out; spongy bone replaces the bridge, a hard bulge; the bulge slims to compact bone and the marrow cavity reopens. Step 2: a timeline on a log scale from one hour to years. For each stage (hematoma, soft callus, bony callus, remodeling) choose how long it runs (hours, days, weeks, or months to years) and the cells doing the work, with the chapter that built them (neutrophils and macrophages, not built in this module; fibroblasts and chondrocytes, 6.5; osteoblasts, 6.4; osteoclasts and osteoblasts, 6.6). After you commit, four bands appear on the timeline: hematoma from the first hour to about two days, soft callus to about three weeks, bony callus to about three months, remodeling for years. Step 3: two columns, the embryo’s endochondral ossification from 6.4 (the cartilage model, then bone collar, calcification of the cartilage, periosteal bud and spongy bone, cavity hollowed, secondary centers) beside the four repair stages. For each embryo step choose its partner in repair (hematoma, soft callus, bony callus, remodeling, or no match); after you commit, links join the columns and the hematoma and the secondary centers are marked no partner. Step 4: a tibia shaft broken at its center. Choose the first days (normal inflammation, or blunted by a high-dose steroid) and the break (held still in a cast, or moving with no cast), predict the bony bridge (on schedule; late; or late and at real risk of never bridging), then run it. The drawing jumps to week 6: a callus of blue cartilage with spongy bone growing in from the ends, its size and bone share set by your choices, and a scale of weeks from 0 to 24 marks the bridge week; a readout gives the callus size, the bone share at week 6 and the bridge week (teaching model). Step 5: the site’s fracture-repair picture, a broken long bone, three magnified circles (a red clot, a callus of cartilage and new bone, remodeled bone with vessels) and the healed bone. A classmate claims that inflammation is bad for bone and the less of it the better a fracture heals; support or refute.
Think · not graded
The lecture scrambles the sequence; the packet has it: hematoma → fibrocartilageA tough, shock-absorbing cartilage found in intervertebral discs and menisci. → spongy → compact. Explain why the soft callus comes before the hard one, which stage is the bottleneck in a cast, and why a drug that suppresses inflammation slows healing.
Spot-check your thinking: true or false?
Check · Fill in the Blanks
The four steps of bone repair, in order.
Evidence card 2
Add it to your evidence board
Repair runs on inflammation — the same cytokines that, with nothing broken, spent her bone instead.
Scene 3 of 5
The Bone That Inflames Instead
RANKL and OPG, the osteoclast on a cytokine leash — and a second gene that lives in bone.
Slide · in production
Inflammation in Bone
The demolition cell is on an immune leash. Pull it with a cytokine for forty years and a scan at thirty-eight is the least surprising finding on the chart.
Prefer the full lecture? Remodeling and Osteoporosis (original video on the site)
Explore
Pull the leash
An osteoblast, a precursor and the bone between them, on a leash. Pull it with RANKL, OPG, cytokines and estrogen, then put her skeleton on the checklist and test the second gene.
Text description of this explore
A dog park, with the osteoclast on a leash. Step 1: a strip of bone with an osteoblast on its surface at the left, RANKL molecules standing up from it like lollipops; Y-shaped OPG decoys that cap RANKL; a round precursor cell of the monocyte line with RANK receptors in the middle; a meter at the top from held to pulled. Set four switches: RANKL on the osteoblast (not shown or shown), the OPG decoy (none or normal), IL-1β and IL-6 (absent, or present as in an attack) and estrogen (normal or low); four buttons load RANKL alone, add OPG, add IL-1β and IL-6, and low estrogen instead. Predict what the precursors do (no osteoclasts form and bone piles up; a few form, matched by the builders, and bone holds; or many form and outrun the builders, and bone thins), then run it: the drawing redraws the RANKL and OPG, moves the leash marker, draws osteoclasts in resorption pits or a new layer of bone, and a readout gives RANKL, OPG, free RANKL, the number of osteoclasts and what the bone does (teaching model, relative units). Step 2: five of her findings (hot shins after exertion, October 1985; monoarthritis with fever, the knee in 1987 then the ankle; night leg pain at 10; low bone density on a DEXA at 38; fever-night back pain). Sort each onto major criterion, minor criterion, cohort finding, or hedge (an open question), and say whether the RANKL leash explains it directly (yes, osteoclasts resorbing bone; no, another tissue carries it; or not known yet). Step 3: five statements about LPIN2 to mark supported, not supported, or open: two failing LPIN2 copies cause Majeed syndrome; lipin-2 and pyrin are both brakes on IL-1β; she has Majeed syndrome; her one LPIN2 copy adds to her MEFV variant in her bones; her fever-night back pain is sacroiliitis. Step 4: suppose a whole-body MRI, which has not been ordered, showed marrow edema in both tibial metaphyses; choose what it would tell you.
Think · not graded
A cytokine that repairs a fracture, loosed with nothing broken, thins a skeleton. Trace IL-1β to the osteoclast through RANKL and OPG, say which of her six findings that pathway explains directly and which need the synovium or the cartilage instead, and say why the Majeed thread is a hedge and not a finding.
Spot-check your thinking: true or false?
Check · Summary
Choose the true statement in each set about inflammation and bone.
Evidence card 3
Add it to your evidence board
The pattern of major and minor FMF criteria at ten and twelve; a cytokine-to-osteoclast pathway with no hormone in it; a second bone gene on the page — the skeletal chart has a mechanism for every entry.
Scene 4 of 5
The Criteria She Met at Ten
Exertional leg pain, erysipelas-like erythema, monoarthritis with fever — the FMF criteria, in a 1985 chart.
Animation · in production · 1 min 50 s
The Criteria She Met at Ten
The Tel Hashomer criteria appear as a form. Major: recurrent fever with serositis — ticked in 1977. Monoarthritis of hip, knee or ankle — the knee, 1987. Minor: exertional leg pain — 1985; erysipelas-like erythema — October 1985. The 2013 DEXA slides in beside the cohort data. The sacroiliac back pain on fever nights. A clinician in 2026 counts the ticks. Caption: enough at twelve; read at fifty-one.
Prefer the full lecture? Fractures and Healing (original video on the site)
Explore
Count the ticks
The criteria as a checklist and her chart as a timeline. Tick each entry with its year before the key, slide to the first year the chart held enough, then write the referral 1987 could have made.
Text description of this explore
A census look: a checklist and a timeline. Step 1: a checklist of FMF criteria, this course’s list (major: fever with serositis; monoarthritis of the hip, knee or ankle; minor: exertional leg pain; erysipelas-like erythema; a response to colchicine; supporting: onset before 20 and attacks that end on their own; rule: one major and two minors, or two majors). Eight entries from her chart, each with the label it was given: night pain in both shins and feet (“growing pains”); hot, red, sharp-edged shins after the mile with a fever that night (“out of shape”); feet, shins and back aching on concrete (“flat feet”); a knee, then an ankle, hot and swollen with a 39 °C fever, gone in four days (“sprain? reactive arthritis”); every attack gone on its own within days, beginning before 20; Mom’s own girlhood leg aches (“it runs in the family”); cartilage piercings that wept for months while a lip healed (“bad piercer”); a DEXA low for her age at 38 with normal estrogen (“perimenopause”). For each choose the criterion it meets (major monoarthritis; minor exertional leg pain; minor erysipelas-like erythema; supporting feature; or none) and its year on the chart (1985; 1986 to 1990; 1987; 1995; 2013). After you commit, the checklist ticks monoarthritis 1987, exertional leg pain 1985, erysipelas-like erythema 1985 and the supporting features, with fever with serositis marked not in the skeletal column and the colchicine response not tried before 2026. Step 2: a timeline of her chart from 1975 to 2026 with a year slider (1985 to 2026) and a choice of reading (the skeletal column only, or the whole chart with her fevers since 1977). Predict whether the chart, read to the end of that year, holds not enough, enough for a clinical diagnosis, or enough only with a gene test, then run it; the major and minor boxes tick and a readout gives the counts and the verdict. Step 3: write the referral the 1987 ER could have made, then compare it with a model answer.
Think · not graded
FMF is diagnosed clinically; the genes are support. Using only the skeletal entries — hot shins after exertion, a knee and an ankle with the fever, night leg pain — say which criteria the chart already showed the pattern of by 1987 and what, besides the criteria, kept the diagnosis forty years away.
Spot-check your thinking: true or false?
Check · Drag the Words
Match each skeletal entry to the FMF criterion it meets.
Evidence card 4
Add it to your evidence board
The pattern of a major criterion and two minor ones from the skeleton alone by 1987 — enough to refer, thirty-nine years before anyone applied the criteria.
Scene 5 of 5
Chart Clue #6
Six labels, one disease, forty years — and the calcium it spent, handed to the next module.
Animation · in production · 2 min
Six Labels, One Skeleton
Six chart cards — growing pains, out of shape, flat feet, a sprain, a bad piercer, perimenopause — each with its year. One by one they flip: an innervated periosteum; a periosteum under exertion; ordinary load on inflamed tissue; a synovium that fills with the fever; cartilage that cannot heal; osteoclasts on a cytokine leash. Behind all six the same molecule. The cards stack into one entry. Caption: the skeleton was not aging. It was inflaming. Chart Clue #6.
Prefer the full lecture? Remodeling and Osteoporosis (original video on the site)
Explore
Flip the labels
Six labels pinned to the wall, face up. Flip each one after you name its tissue and its cytokine step, sort the six with two hedges, then build the sentence and follow the calcium out of the bone.
Text description of this explore
A wall of clipboards. Step 1: six chart tiles face up, each on lined paper with its year: “growing pains” (1985, age 10: night pain in both shins and feet, worst after active days); “out of shape” (October 1985: hot, swollen shins after the mile, sore in the bone); “flat feet” (1986 to 1990: feet, shins and back aching on concrete); “a sprain” (1987: a knee, then an ankle, hot and swollen with a fever); “a bad piercer” (1995: helix and nostril piercings that wept for months); “perimenopause” (2013: a DEXA low for her age at 38). For each choose the tissue (periosteum, synovium, cartilage or osteoclasts) and the cytokine step (IL-1β sensitizes pain nerves; IL-1β floods a joint lining; IL-1β re-injures avascular tissue; or IL-1β and IL-6 raise RANKL and lower OPG). After you commit, each tile flips to show its tissue and mechanism. Step 2: eight entries, the six labels plus the L4/L5 disc at 40 (like Mom’s) and back pain worst on fever nights. Sort each into bone (periosteum and osteoclasts), synovium, cartilage, or needs more than this module, and choose the evidence that matters (she stopped growing at 16 and the pain did not; a fever that night and hot, red skin; shins and a back, not only arches; no injury, a fever and a second joint; the same piercer’s lip piercing healed; normal cycles and estrogen at 38; or not settled, asked and not answered). Step 3: a sentence with six numbered blanks: Six skeletal labels are (1) (2)-driven (3) disease of bone, cartilage and synovium. The skeleton was not (4) and was never (5); it was (6). For each blank choose a word from the bank: one, six, IL-1β/IL-6, estrogen, remodeling, aging, fragile, inflaming. After you commit the sentence fills in. Step 4: put five steps in order to trace the calcium from an osteoclast in 1985 to a contraction in Module 7.
Think · not graded
Each of the six labels was reasonable on its own day. State the one assumption all six shared, name the finding that first refuted it (and the year), and write Chart Clue #6 in a sentence a 1987 ER could have understood.
Spot-check your thinking: true or false?
Check · Multiple Choice
Select the phrases that state Chart Clue #6; leave the dismissals.
Evidence card 5
Add it to your evidence board
Chart Clue #6: a lifetime skeletal list — night pain, hot shins, concrete years, a knee with the fever, piercings, a scan — is one IL-1β/IL-6 remodeling disease, not six labels of growth, fitness, shoes, luck and age.
4
Your evidence board
Every scene gave you an evidence card, and the chart adds more. Sort each card into the column it supports: One inflammatory disease across bone, cartilage and synovium, Needs more than this module, or Six unrelated labels of growth, fitness and age. Some cards can honestly go in more than one place — that’s allowed, and the feedback tells you which cards decide the case.
5
Your verdict
Time to decide. Look back at your bet, then build your verdict from statements that hold up — no writing needed.
Look back at your prediction
Six skeletal labels across forty years — the reading that fits best is…
Find the one you chose at the top. Does the evidence support it, refute it, or revise it?
- Six ordinary things that happen to many people, each true on its own day
- A weak skeleton — some inherited fragility nobody named
- One inflammatory disease signing its name in bone, cartilage and synovium from the age of ten
Build your verdict · no writing
Choose the statement that holds in each set. The ones you keep become your argument.
6
The finding
Finding · Clue #6
The Skeleton Was Not Aging
1985–2026: six skeletal labels — growing pains, out of shape, flat feet, a sprain, a bad piercer, perimenopause — each assuming an inert tissue. Chart entry: living, innervated bone with osteoclasts on a cytokine leash; a synovium that fills with the fever; cartilage that cannot heal what IL-1β re-injures; the criteria’s pattern by 1987, density low by 38. Read whole: one IL-1β/IL-6 remodeling disease. Chart Clue #6. Held open: the LPIN2 copy and the fever-night back pain — asked, not answered; and the calcium bone spent, which Module 7 needs for a contraction.
Next · Module 7
Muscular Tissue
1988, age 13: the backpack year — legs like lead after gym, soaked and shaking, and a cramp on the first day of every period. The calcium that left her bones here is what a sarcomere needs next.
Reliable information on rare diseases
NORD · NIH GARD · Orphanet · MedlinePlus Genetics: FMF · FMF & AID Global Association · Autoinflammatory Alliance · Global Genes · Amyloidosis Foundation
Stina has one rare disease. In the United States, about 1 in 10 people live with one of the more than 7,000 known rare diseases. These organizations are where patients, families and clinicians go for trustworthy information.
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← Familial Mediterranean Fever — case home
All pages for Module 6 — The Skeletal System
6.0 Module Overview
6.1 Growing Pains
6.2 The Fitness Test
6.3 Pillars and Trusses
6.4 She’ll Grow Out of It
6.5 The Joint That Swelled With the Fever
6.6 Five Percent a Week
6.7 Broken, Mended, Read Whole
6.8 Conclusion and Assessment
6.9 The Evidence Behind the Case
All Modules
- Anatomical Language, Membranes & Homeostasis
- Just Enough Chemistry
- The Cell & Its Transport
- Making Cells & Proteins
- The Integumentary System
- The Skeletal System
- The Muscular System
- Nervous Tissue & the Senses
- The Spinal Cord
- The Brain & the Blood–Brain Barrier
- The Autonomic Nervous System
- Special Senses (in developmentThe process of growth and differentiation.)
- The Endocrine System
- Blood
- The Heart
- Blood Vessels
- The Digestive System
- The Respiratory System
- The Urinary System
- Fluids, Electrolytes & Acid–Base Balance
- The Reproductive System
- The Immune System
List of terms
- fracture
- cartilage
- spine
- erythema
- anatomy
- physiology
- skin
- hematoma
- endosteum
- collagen
- soft callus
- spongy bone
- compact bone
- endochondral ossification
- osteoclast
- anemia
- edema
- growth
- peritoneum
- fact
- tibia
- fibrocartilage
- development